PBPK (Physiologically based pharmacokinetic)Modeling

  • PBPK is a computer simulation tool (Numerical integration).
  • Fundamental objective of PBPK
    • To identify the main organs/tissues involved in the disposition of the small molecule/biologics and to correlate ADME within and among these organs/ tissues in an integrated and biologically feasible manner.
  • Parameters required for PBPK modeling
    1. Physiological parameters,
    2. Thermodynamic parameters
    3. Biochemical parameters
  • Interactive PBPK model-simulates the interactions between and among chemicals in a mixture.
  • Systems biologyIntegrates computational and experimental sciences in an effort to describe and understand entire biological systems

REFERENCES

  • https://quizlet.com/143697361/pbpk-flash-cards/