PBPK is a computer simulation tool (Numerical integration).
Fundamental objective of PBPK
To identify the main organs/tissues involved in the dispositionof the small molecule/biologics and to correlate ADME within and among these organs/ tissues in an integrated and biologically feasible manner.
Parameters required for PBPK modeling
Interactive PBPK model-simulates the interactions between and among chemicals in a mixture.
Systems biology–Integrates computational and experimental sciences in an effort to describe and understand entire biological systems